Precision Micro- and Nanoscale Drug Delivery
Developing micro- and nanoscale systems for metabolic reactivation, dry powder inhalation and nucleic acid delivery, offering new approaches to targeted therapy for major diseases
Conventional drug therapies often lack targeting, readily meet drug resistance and suffer from low bioavailability. This direction tackles these problems with new delivery mechanisms and carrier engineering at the micro- and nanoscale. First, nutrient nanoformulations reshape the metabolic reactivation pathway of tumors to precisely suppress malignant tumor growth. Second, advances in particle engineering and smart delivery devices are yielding dry powder inhalation formulations with high deep-lung deposition, opening new routes for treating respiratory diseases and delivering vaccines. Third, a safe and efficient cationic peptide/siRNA nanocomplex delivery platform overcomes the degradation and low delivery efficiency that limit small nucleic acid drugs. The team is working to connect carrier design, preclinical evaluation and scaled-up manufacturing, providing innovative clinical solutions for malignant tumors and major chronic diseases.
