Organelle Interactions
Combining super-resolution imaging with deep learning to track how multiple organelles interact in real time, revealing the mechanisms of life and offering a street-view-style map for precision diagnosis and therapy
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Organelle-Targeted Precision Diagnosis and Therapy: A New Era in Medicine
Focusing on organelle-targeted therapy to open a new frontier in precision medicine
100 M+Research Grants
450+Publications
20+Patents
60+Team Members
RESEARCH
Research
Regulating organelle function to explore new frontiers in precision medicine
Digital-Intelligent High-End Bioimaging
Combining super-resolution optics with intelligent algorithms to develop high-end imaging instruments in-house, providing core tools for analyzing living-cell dynamics and for precision diagnosis and therapy
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Next-Generation Rapid Antimicrobial Susceptibility Testing
Advancing early subcellular phenotyping of single bacteria and super-resolution imaging to build a two-hour rapid susceptibility testing system that guides precise treatment of severe drug-resistant infections
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Virtual Cell
Combining in-house super-resolution imaging with AI algorithms to build digital-twin models of virtual cells for target discovery and accurate prediction of drug efficacy
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Precision Micro- and Nanoscale Drug Delivery
Developing micro- and nanoscale systems for metabolic reactivation, dry powder inhalation and nucleic acid delivery, offering new approaches to targeted therapy for major diseases
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Organoids
Building and regulating neural organoids with multimodal and AI technologies to explore disease mechanisms, brain–computer interfaces and organoid intelligence
Learn moreOUR TEAM
Team members
60+researchers
About Us
Organelles DiTelligence Team
The Organelle-targeted Precision Diagnosis & Therapy (ODT) team is led by Dayong Jin, Fellow of the Australian Academy of Technological Sciences and Engineering, Chair Professor at Eastern Institute of Technology, Ningbo, and Dean of its School of Biomedical Engineering. The team is defined by its integration of medicine and engineering, its concentration of top talent and its international outlook. Based at the Zhejiang Engineering Research Center for Organelle Precision Diagnosis and Therapy, it brings together academicians, nationally recognized talents, young faculty, postdoctoral fellows and engineers in a multi-tiered research and engineering team.
The team has founded the Yinzhou (EIT) Digital Intelligence Bio-Innovation Institute and Ningbo ODT Organelle Diagnosis and Therapy Technology Co., Ltd. The institute hosts a Zhejiang Provincial Postdoctoral Workstation, and the company is backed as a Category A high-end start-up team in science and technology innovation under the Yinzhou District High-Level Talent Program. Together they carry the team's own research from technology development through clinical validation to industrial application.
Medicine × Engineering
Talent
Global
PRINCIPAL INVESTIGATOR
Dayong Jin
Professor Dayong Jin is a Fellow of the Australian Academy of Technological Sciences and Engineering, Dean of the School of Biomedical Engineering in the Faculty of Engineering at Eastern Institute of Technology, Ningbo, Director of the Zhejiang Engineering Research Center for Organelle Precision Diagnosis and Therapy, head of the Organelle-targeted Precision Diagnosis & Therapy (ODT) team and a doctoral supervisor. Working in biophotonics on frontier questions about organelles in living cells, he has developed high-throughput super-resolution imaging instruments, ultrasensitive single-molecule functional probes and digital-intelligent analysis technologies, building an integrated research program that runs from fundamental research to translation.
- Organelle interactions and precision theranostics
- Rapid antimicrobial resistance testing
- Nanomedicine screening and delivery
- Digital-intelligent bioimaging instruments
- Organoid intelligence and spatial omics
- Biomedical AI models and algorithms
Faculty
Postdoctoral Fellows
Cindy RenXinying RenVirtual cells, Antifungal resistance mechanisms in pathogenic fungi
Manling ChenOrganelle isolation and purification, Organelle delivery therapy
Haixia YeOrganoid construction, Organ-on-a-chip, Organoid intelligence
Mingkai WangBiomaterials for tissue repair and antibacterial applications
Xijing LiuOrganoids-on-chips
PUBLICATIONS & PATENTS
Publications & patents
Selected papers
- 2026Translating NIR-II imaging into clinical practice: advances and strategiesKehong Lv, Jing Yao, Jiajia Zhou, Cuiling Zhang, Dayong Jin , Shihui WenCoordination Chemistry Reviews
- 2026Surface dye-coordination for efficient upconversion nanosystemsZhangqiang Li, Yun Xing, Jiajia Zhou, Guochen Bao, Dayong Jin and Shihui WenScience China Materials
- 2026Spatial transcriptome for cell segmentationNannan Wang & Dayong JinNature Computational Science
- 2026Lattice and ligand engineering for hierarchical heterogeneous nanocrystalsRui Wang, Mengxiang Qiao, Shihui Wen , Xian Qin , Xiaoya Zhang, Linqing Guo , Yanyan Liu, Li Song, Hongyu Chen , and Dayong JinProceedings of the National Academy of Sciences
- 2025Pyramidal lens enables mesoscale structured illumination by surpassing the spatial bandwidth limit of spatial light modulatorsGang Wen, HongJin Li, Hao Jie Wang, Qin Ke, JingQian Wang,Xi Zhu, Yin Chen DaYong Jin, Shih-Chi Chen, AND Karl Zhang haoOptica
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- 2025Fast segmentation and multiplexing imaging of organelles in live cellsZhanghao Karl, Li Meiqi, Chen Xingye, Liu Wenhui, Li Tianling, Wang Yiming, Su Fei, Wu Zihan, Shan Chunyan, Wu Jiamin, Zhang Yan, Fu Jingyan, Xi Peng, Jin DayongNature Communications
- 2025Recent advances in nanomaterials for integrated phototherapy and immunotherapyZhuqing Sun, Nannan Wang , Yelin Wu , Shihui Wen , Dayong JinCoordination Chemistry Reviews
- 2024Nutrient-delivery and metabolism reactivation therapy for melanoma, Nature NanotechnologyYang Chen, Chaochao Wang, Yelin Wu, Ya Wang, Yun Meng, Fan Wu, Huilin Zhang, Yuen Yee Cheng, Xingwu Jiang, Jieyun Shi, Huiyan Li, Peiran Zhao, Jinfeng Wu, Bin Zheng, Dayong Jin, Wenbo BuNature Nanotechnology
- 2024Non-Faradaic optoelectrodes for safe electrical neuromodulationJian Chen, Yanyan Liu, Feixiang Chen, Mengnan Guo, Jiajia Zhou, Pengfei Fu, Xin Zhang, Xueli Wang, He Wang, Wei Hua, Jinquan Chen, Jin Hu, Ying Mao, Dayong Jin, Wenbo BuNature Communications
- 2023Bone disease imaging through the nearinfrared- II windowChao Mi, Xun Zhang, Chengyu Yang, Jianqun Wu, Xinxin Chen, Chenguang Ma, Sitong Wu, Zhichao Yang, Pengzhen Qiao, Yang Liu, Weijie Wu, Zhiyong Guo, Jiayan Liao, Jiajia Zhou, Ming Guan, Chao Liang, Chao Liu, Dayong JinNature Communications
- 2021Optical tweezers beyond refractive index mismatch using highly doped upconversion nanoparticlesXuchen Shan, Fan Wang, Dejiang Wang, Shihui Wen, Chaohao Chen, Xiangjun Di, Peng Nie, Jiayan Liao, Yongtao Liu, Lei Ding, Peter J. Reece, Dayong JinNature Nanotechnology
- 2020Single-particle spectroscopy for functional nanomaterialsJiajia Zhou, Alexey I. Chizhik, Steven Chu, Dayong JinNature
- 2020Nanorods with multidimensional optical information beyond the diffraction limitShihui Wen, Yongtao Liu, Fan Wang, Gungun Lin, Jiajia Zhou, Bingyang Shi, Yung Doug Suh, Dayong JinNature Communications
- 2019Axial localization and tracking of self-interference nanoparticles by lateral point spread functionsYongtao Liu, Zhiguang Zhou, Fan Wang, Günter Kewes, Shihui Wen, Sven Burger, Majid Ebrahimi Wakiani, Peng Xi, Jiong Yang, Xusan Yang, Oliver Benson, Dayong JinNature Communications
- 2019Future and challenges for hybrid upconversion nanosystemsShihui Wen, Jiajia Zhou, P. James Schuck, Yung Doug Suh, Timothy W. Schmidt, Dayong JinNature Photonics
- 2018Advances in highly doped upconversion nanoparticlesShihui Wen, Jiajia Zhou, Kezhi Zheng, Artur Bednarkiewicz, Xiaogang Liu, Dayong JinNature Communications
- 2018Activation of the surface dark-layer to enhance upconversion in a thermal fieldJiajia Zhou, Shihui Wen, Jiayan Liao, Christian Clarke, Sherif Abdulkader Tawfik, Wei Ren, Chao Mi, Fan Wang, Dayong JinNature Photonics
- 2018Multi-photon near-infrared emission saturation nanoscopy using upconversion nanoparticlesChaohao Chen, Fan Wang, Shihui Wen, Qian Peter Su, Mike C. L. Wu, Yongtao Liu, Baoming Wang, Du Li, Xuchen Shan, Mehran Kianinia, Igor Aharonovich, Milos Toth, Shaun P. Jackson, Peng Xi, Dayong JinNature Communications
- 2018Nanoparticles for super-resolution microscopy and single-molecule trackingDayong Jin, Peng Xi, Baoming Wang, Le Zhang, Jörg Enderlein, Antoine M. van Oijen Nature Methods
- 2017Amplified stimulated emission in upconversion nanoparticles for superresolution nanoscopyYujia Liu, Yiqing Lu, Xusan Yang, Xianlin Zheng, Shihui Wen, Fan Wang, Xavier Vidal, Jiangbo Zhao, Deming Liu, Zhiguang Zhou, Chenshuo Ma, Jiajia Zhou, James A. Piper, Peng Xi, Dayong JinNature
- 2016Three-dimensional controlled growth of monodisperse sub-50 nm heterogeneous nanocrystalsDeming Liu, Xiaoxue Xu, Yi Du, Xian Qin, Yuhai Zhang, Chenshuo Ma, Shihui Wen, Wei Ren, Ewa M. Goldys, James A. Piper, Shixue Dou, Xiaogang Liu. Dayong JinNature Communications
Patents
CN115251839BA Near-Infrared-II Light-Sheet System for Three-Dimensional In Vivo Imaging
CN115866424BA rolling-shutter exposure imaging method and imaging device based on sCMOS
20230288337HIGH DIMENSIONAL FINGERPRINTS OF SINGLE NANOPARTICLES AND THEIR USE IN MULTIPLEXED DIGITAL ASSAYS
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CN116157352AHigh-Dimensional Fingerprints of Single Nanoparticles and Their Use in Multiplexed Digital Assays
US20200088982A SYSTEM AND METHOD FOR MICROSCOPY
PLATFORM & TRANSLATION
Platform & translation
Moving our research from the bench toward clinical validation and industry
NEWS & EVENTS
All newsNews & events
LatestODT 2026 International Conference on Organelle-targeted Precision Diagnosis and Therapy17–19 September 2026 · Ningbo, ChinaConference details282026.10A Glimpse into an Academician’s Lab | Observing the Microscopic Through a Lens, Exploring the Profound with Intelligence232026.10Team News2025 Academic Conference on Organelle-targeted Precision Diagnosis and Therapy Concludes Successfully232026.10ODT 2026 International Conference on Organelle-targeted Precision Diagnosis and Therapy Held SuccessfullyPast conferenceODT 2025 International Conference on Organelle-targeted Precision Diagnosis and Therapy20–21 September 2025 · Ningbo, China
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